Palonosetron Impurity 27 - Names and Identifiers
Name | Palonosetron Intermediate
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Synonyms | Palonosetron Impurity 20 Palonosetron Impurity 1 Palonosetron Impurity 25 Palonosetron Impurity 27 Palonosetron Intermediate (S)-N-(Quinuclidin-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxaMide (S)-N-(quinuclidin-3-yl)-5,6,7,8- tetrahydronaphthalene-1-carboxamide N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide (S)-N-1-azabicyclo[2.2.0]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide (S)-N-(1-Azabicyclo[2.2.2]Oct-3-Yl)-5,6,7,8-Tetrahydro-1-Naphthalenecarboxamide (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide
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CAS | 135729-78-1
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InChI | InChI=1/C18H24N2O/c21-18(19-17-12-20-10-8-14(17)9-11-20)16-7-3-5-13-4-1-2-6-15(13)16/h3,5,7,14,17H,1-2,4,6,8-12H2,(H,19,21)/t17-/m1/s1 |
Palonosetron Impurity 27 - Physico-chemical Properties
Molecular Formula | C18H24N2O
|
Molar Mass | 284.4 |
Density | 1.17 |
Melting Point | 157-159oC |
Boling Point | 439.2°C at 760 mmHg |
Flash Point | 219.4°C |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 6.48E-08mmHg at 25°C |
Appearance | Solid |
Color | White |
Storage Condition | Refrigerator |
Refractive Index | 1.609 |
Use | Intermediate |
Palonosetron Impurity 27 - Introduction
Palonosetron hydrochloride intermediate is a chemical substance whose chemical name is 1-methyl -4-aryl -4-butene -1-amine hydrochloride. The following is a description of its nature, use, preparation and safety information:
Nature:
-Palonosetron hydrochloride intermediate is a colorless to light yellow solid with a special smell.
-It is soluble in water at room temperature, but has low solubility in organic solvents.
-It is a strong organic base with a pKa value of about 7-8.
Use:
-Palonosetron hydrochloride intermediates are widely used in the synthesis of various drugs and intermediates in pharmaceutical chemistry.
-It can be used as a key raw material for the synthesis of antiepileptic drugs, anticancer drugs, antidepressants, etc.
-In addition, it can also be used for the synthesis of dyes and dye intermediates.
Preparation Method:
-palonosetron hydrochloride intermediates are generally prepared by chemical synthesis.
-The specific synthesis route and reaction conditions can be determined according to specific needs, and usually involve the use of corresponding organic synthesis reagents and reaction conditions.
Safety Information:
-Palonosetron hydrochloride intermediate is an organic compound, and attention should be paid to its safe use.
-Wear appropriate personal protective equipment such as gloves, glasses and lab coats during operation.
-Avoid contact with skin, eyes and respiratory tract. If splashed, rinse immediately with plenty of water.
-In the process of storage and handling, should avoid contact with oxidants and strong acids and bases and other substances that are prone to reaction.
-It is recommended to operate in a professional laboratory environment and operate in accordance with relevant safety standards and operating procedures.
Last Update:2024-04-09 20:52:54